Preparative Requirements for Volatile, Semi-volite, and Gas Chromatography Quality Control
Effective Date: 07/2008
Point of Contact: Quality Engineer for Regulatory Programs
| Quality Control Requirements | Frequency | Frequency | Failure Action |
|---|---|---|---|
| Method blank | 1 per batch | < EQL (See Organic Quality Control exhibit) | Investigate against samples and client DQRs. Correct. Re-prepare as required. |
| BS or LCS |
1 per batch (Blank, spiked with surrogate) 1 per batch |
See Organic Quality Control exhibit | Investigate against samples and client DQRs. Correct. Re-prepare and analyze as required. |
| MS and MSD (Accuracy) (Precision) |
1 set per batch | See Organic Quality Control exhibit | Evaluate. If lab error, re-prepare and analyze. If matrix driven, evaluate against DQRs, notify client if still unacceptable, discuss in narrative. |
| Surrogate | Each sample, QC sample, standard, and blank. | See Organic Quality Control exhibit | Evaluate. If lab error, re-prepare and analyze. If matrix driven, evaluate against DQRs, notify client if still unacceptable, discuss in narrative. |
Total Carbon, Total Inorganic Carbon, and Total Organic Compound |
|||
| Duplicate | 1 per batch | <20% RPD when >10 times IDL | Evaluate. If lab error, re-prepare and analyze. If matrix driven, evaluate against DQRs, notify client if still unacceptable, discuss in narrative. |
| MS | 1 per batch | Recommended 75% to 125% |
Evaluate. If lab error, re-prepare and analyze. If matrix driven, evaluate against DQRs, notify client if still unacceptable, discuss in narrative. |
| Blank Spike or Laboratory Control Sample |
1 per batch | 80% to 120% Vendor or Statistical |
Investigate, evaluate against DQRs, correct, re-prepare and analyze if applicable. |
| Method blank | 1 per batch | <EQL | Investigate, evaluate against DQRs, correct, re-prepare and analyze if applicable. |
BS = Blank Spike
EQL = Estimated quantitation limit
MS = Matrix spike
MSD = Matrix spike duplicate
RPD = relative percent difference.