Contents

Analytical Requirements for Semivolatile (Gas Chromatography/MassSpectrometry) Quality Control

Effective Date: 11/01
Point of Contact: Quality Engineer for Regulatory Programs

Quality Control Requirements	Frequency	Criteria	Failure Action
Tune	Once on a 12-hour clock	See Minimum Calibration Requirements for Gas Chromatograph/Mass Spectrometer System exhibit.	Investigate. Correct.
Continuing Calibration Verification	Once on a 12-hour clock	See Organic Quality Control exhibit	Investigate. Correct. Reanalyze.
Internal standard	Each sample, QC sample, blank, and standard	See Organic Quality Control exhibit	Investigate. Correct and reanalyze or re-prepare.
Qualitative identification	Each sample	Compare to spectra generated and retention times	Report any unusual circumstances in narrative.
Quantitation	Each sample. See also Calibration Requirements for Organic Analyses for surrogate and internal standard.	Calculate off continuing calibration	Report any unusual circumstances in narrative.